PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes

Rehman, I; Basu, SM; Das, SK; Bhattacharjee, S; Ghosh, A; Pommier, Y; Das, BB

Das, BB (reprint author), Indian Assoc Cultivat Sci, Dept Biol Chem, Lab Mol Biol, 2A & B,Raja SC Mullick Rd, Kolkata 700032, India.; Pommier, Y; Das, BB (reprint author), NCI, Dev Therapeut Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.; Pommier, Y;

NUCLEIC ACIDS RESEARCH, 2018; 46 (11): 5601

Abstract

Human tyrosyl-DNA phosphodiesterases (TDP) hydrolyze the phosphodiester bond between DNA and the catalytic tyrosine of Top1 to excise topoisomerase I ......

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