PARP inhibition protects mitochondria and reduces ROS production via PARP-1-ATF4-MKP-1-MAPK retrograde pathway

Hocsak, E; Szabo, V; Kalman, N; Antus, C; Cseh, A; Sumegi, K; Eros, K; Hegedus, Z; Gallyas, F; Sumegi, B; Racz, B

Hocsak, E (reprint author), Univ Pecs, Dept Biochem & Med Chem, Med Sch, Szigeti U 12, H-7624 Pecs, Hungary.

FREE RADICAL BIOLOGY AND MEDICINE, 2017; 108 ( ): 770

Abstract

Oxidative stress induces DNA breaks and PARP-1 activation which initiates mitochondrial reactive oxygen species (ROS) production and cell death throug......

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