A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis

Zhang, J; Gao, XF; Wei, MM; Li, YH; Yang, G; Yang, C; Yu, L

Yu, L (corresponding author), Shenzhen Univ, Shenzhen Key Lab Precis Med Hematol Malignancies, Shenzhen Univ Hlth Sci Ctr,Clin Med Acad, Shenzhen Univ Gen Hosp,Int Canc Ctr,Dept Hematol, Xueyuan Ave 1098, Shenzhen 518000, Guangdong, Peoples R China.; Yang, G; Yang, C (corresponding author), Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, 38 Tongyan Rd, Tianjin 300350, Peoples R China.

CLINICAL SCIENCE, 2021; 135 (14): 1751

Abstract

Epigenetic dysregulation has long been identified as a key driver of leukemogenesis in acute myeloid leukemia (AML). However, epigenetic drugs such as......

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