CCDC50 suppresses NLRP3 inflammasome activity by mediating autophagic degradation of NLRP3

Lin, YX; Li, ZB; Wang, YC; Tian, T; Jia, PH; Ye, Y; He, M; Yang, ZX; Li, CM; Guo, DY; Hou, PP

Guo, DY; Hou, PP (通讯作者)，Sun Yat Sen Univ, Ctr Infect & Immun Study CIIS, Sch Med, MOE Key Lab Trop Dis Control, Shenzhen, Peoples R China.

EMBO REPORTS, 2022; 23 (5):

Abstract

The NLRP3-directed inflammasome complex is crucial for the host to resist microbial infection and monitor cellular damage. However, the hyperactivatio......

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