High levels of Notch intracellular cleaved domain are associated with stemness and reduced bevacizumab efficacy in patients with advanced colon cancer

Negri, F; Bozzetti, C; Pedrazzi, G; Azzoni, C; Bottarelli, L; Squadrilli, A; Lagrasta, C; Tamagnini, I; Bisagni, A; Ragazzi, M; Porzio, R; Tomasello, G; Mori, D; Leonardi, F; Gnetti, L; Crafa, P; Sala, R; Cascinu, S

Negri, F (reprint author), Univ Hosp Parma, Med Oncol Unit, Via Gramsci 14, I-43126 Parma, Italy.

ONCOLOGY REPORTS, 2019; 42 (6): 2750

Abstract

delta-like ligand 4 (DLL4)-Notch signaling is associated with tumor resistance to anti-vascular endothelial growth factor (VEGF) therapy. Furthermore,......

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