Lactadherin promotes microvesicle clearance to prevent coagulopathy and improves survival of severe TBI mice

Zhou, Y; Cai, W; Zhao, ZL; Hilton, T; Wang, M; Yeon, J; Liu, W; Zhang, FY; Shi, FD; Wu, XP; Thiagarajan, P; Li, M; Zhang, JN; Dong, JF

Zhang, JN (reprint author), Tianjin Med Univ, Dept Neurosurg, Gen Hosp, Tianjin, Peoples R China.; Dong, JF (reprint author), Bloodworks Res Inst, 1551 Eastlake Ave East, Seattle, WA 98102 USA.; Li, M (reprint author), Lanzhou Univ, Inst Pathol, Sch Basic

BLOOD, 2018; 131 (5): 563

Abstract

Coagulopathy is common in patients with traumatic brain injury (TBI) and predicts poor clinical outcomes. We have shown that brain-derived extracellul......

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