Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex

Hoch, DG; Abegg, D; Hannich, JT; Pechalrieu, D; Shuster, A; Dwyer, BG; Wang, C; Zhang, XJ; You, QD; Riezman, H; Adibekian, A

Adibekian, A (corresponding author), Scripps Res Inst, Dept Chem, 130 Scripps Way, Jupiter, FL 33458 USA.

CELL CHEMICAL BIOLOGY, 2020; 27 (5): 586

Abstract

In this study, we identify the natural product gambogic acid as well as structurally related synthetic xanthones as first-in-class covalent inhibitors......

Full Text Link