ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma-MedSci.cn

ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma

Xi, XN; Liu, N; Wang, QQ; Chu, YH; Yin, Z; Ding, YH; Lu, YX

Ding, YH; Lu, YX (reprint author), Nankai Univ, Coll Pharm, Tianjin 300350, Peoples R China.; Ding, YH; Lu, YX (reprint author), Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China.

CELL DEATH & DISEASE, 2019; 10 ():

Abstract

PAI-1 plays significant roles in cancer occurrence, relapse and multidrug resistance and is highly expressed in tumours. ACT001, which is currently in......

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