Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

Yang, ZG; Shi, JF; Xie, J; Wang, YF; Sun, JY; Liu, TZ; Zhao, YR; Zhao, XT; Wang, XM; Ma, YF; Malkoc, V; Chiang, CL; Deng, WY; Chen, YX; Fu, Y; Kwak, KJ; Fan, YM; Kang, C; Yin, CC; Rhee, J; Bertani, P; Otero, J; Lu, W; Yun, K; Lee, AS; Jiang, W; Teng, LS; Kim, BYS; Lee, LJ

Lee, LJ (corresponding author), Ohio State Univ, Dept Chem & Biomol Engn, Columbus, OH 43210 USA.; Teng, LS (corresponding author), Jilin Univ, Sch Life Sci, Changchun, Peoples R China.; Kim, BYS (corresponding author), Mayo Clin, Dept Neurol Surg, Jacksonville, FL 32224 USA.; Kim, BYS (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA.

NATURE BIOMEDICAL ENGINEERING, 2020; 4 (1): 69

Abstract

A cellular-nanoporation method produces large quantities of exosomes containing therapeutic mRNAs and targeting peptides that restore tumour-suppresso......

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