L-DOPA-Induced Motor Impairment and Overexpression of Corticostriatal Synaptic Components Are Improved by the mGluR5 Antagonist MPEP in 6-OHDA-Lesioned Rats

Huang, YX; Shu, HY; Li, L; Zhen, TL; Zhao, JY; Zhou, XJ; Luo, WF

Luo, WF (reprint author), Soochow Univ, Affiliated Hosp 2, Dept Neurol, 1055 Sanxiang Rd, Suzhou 215004, Peoples R China.; Zhou, XJ (reprint author), Nanjing Med Univ, Affiliated Hosp, Changzhou Peoples Hosp 2, Lab Neurol Dis,Dept Neurol, 29 Xinglong Alle

ASN NEURO, 2018; 10 ():

Abstract

Levodopa (L-DOPA) is still the most effective drug for the treatment of Parkinson's disease (PD). However, the long-term therapy often triggers L-DOPA......

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