Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis

Yin, CQ; Zhu, B; Zhang, T; Liu, TZ; Chen, SY; Liu, Y; Li, X; Miao, X; Li, SS; Mi, X; Zhang, J; Li, L; Wei, G; Xu, ZX; Gao, XM; Huang, CH; Wei, Z; Goding, CR; Wang, P; Deng, XM; Cui, RT

Cui, RT (reprint author), Boston Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02118 USA.; Deng, XM (reprint author), Xiamen Univ, State Key Lab Cellular Stress Biol, Innovat Ctr Cell Signaling Network, Sch Life Sci, Xiamen 361102, Fujian, Pe

CELL, 2019; 176 (5): 1113

Abstract

Activating mutations in NRAS account for 20%-30% of melanoma, but despite decades of research and in contrast to BRAF, no effective anti-NRAS therapie......

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