Targeting the WEE1 kinase strengthens the antitumor activity of imatinib via promoting KIT autophagic degradation in gastrointestinal stromal tumors

Liu, WZ; Zeng, XY; Yin, YP; Li, CG; Yang, WC; Wan, WZ; Shi, L; Wang, GB; Tao, KX; Zhang, P

Zhang, P (corresponding author), Huazhong Univ Sci & Technol, Dept Gastrointestinal Surg, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China.

GASTRIC CANCER, 2020; 23 (1): 39


Background Activating mutation of KIT or PDGFRA is the primary molecular mechanism for gastrointestinal stromal tumors (GISTs). Although imatinib has ......

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