YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m(6)A modification to activate NE-kappa B and promote the malignant progression of glioma

Chai, RC; Chang, YZ; Chang, X; Pang, B; An, SY; Zhang, KN; Chang, YH; Jiang, T; Wang, YZ

Chai, RC; Jiang, T; Wang, YZ (corresponding author), Capital Med Univ, Beijing Neurosurg Inst, Dept Mol Neuropathol, Dept Neuropathol, 119 Nan Si Huan Xi Rd, Beijing 100050, Peoples R China.; Jiang, T; Wang, YZ (corresponding author), Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, 119 Nan Si Huan Xi Rd, Beijing 100050, Peoples R China.; Chai, RC; Jiang, T; Wang, YZ (corresponding author), Chinese Glioma Genome Atlas Network CGGA, Beijing, Peoples R China.

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021; 14 (1):

Abstract

Background: The prognosis for diffuse gliomas is very poor and the mechanism underlying their malignant progression remains unclear. Here, we aimed to......

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