BP-1T, an antiangiogenic benzophenone-thiazole pharmacophore, counteracts HIF-1 signalling through p53/MDM2-mediated HIF-1 alpha proteasomal degradation

Thirusangu, P; Vigneshwaran, V; Prashanth, T; Avin, BRV; Malojirao, VH; Rakesh, H; Khanum, SA; Mahmood, R; Prabhakar, BT

Prabhakar, BT (reprint author), Kuvempu Univ, Postgrad Dept Studies & Res Biotechnol, Sahyadri Sci Coll Autonomous, Mol Biomed Lab, Shivamogga 577203, Karnataka, India.

ANGIOGENESIS, 2017; 20 (1): 55

Abstract

Hypoxia is a feature of all solid tumours, contributing to tumour progression. Activation of HIF-1 alpha plays a critical role in promoting tumour ang......

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