CRISPR/Cas9-mediated metabolic pathway reprogramming in a novel humanized rat model ameliorates primary hyperoxaluria type 1

Zheng, R; Li, YY; Wang, LR; Fang, XL; Zhang, JQ; He, L; Yang, L; Li, DL; Geng, HQ

Geng, HQ (corresponding author), Shanghai Jiao Tong Univ, Dept Pediat Urol, Xinhua Hosp, Sch Med, 1665 KongJiang Rd, Shanghai 200092, Peoples R China.; Li, DL (corresponding author), East China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China.; Li, DL (corresponding author), East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China.

KIDNEY INTERNATIONAL, 2020; 98 (4): 947

Abstract

Primary hyperoxaluria type I is caused by mutations in the alanine glyoxylate aminotransferase gene (AGXT), leading to accumulation of glyoxylate and ......

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