Inhibition of the ALDH18A1-MYCN positive feedback loop attenuates MYCN-amplified neuroblastoma growth

Guo, YF; Duan, JJ; Wang, J; Li, L; Wang, D; Liu, XZ; Yang, J; Zhang, HR; Lv, J; Yang, YJ; Yang, ZY; Cai, J; Liao, XM; Tang, T; Huang, TT; Wu, F; Yang, XY; Wen, Q; Bian, XW; Yu, SC

Yu, SC (corresponding author), Army Med Univ, Third Mil Med Univ, Southwest Hosp, Dept Stem Cell & Regenerat Med, Chongqing 400038, Peoples R China.; Bian, XW; Yu, SC (corresponding author), Army Med Univ, Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing 400038, Peoples R China.; Bian, XW; Yu, SC (corresponding author), Army Med Univ, Third Mil Med Univ, Southwest Hosp, Southwest Canc Ctr, Chongqing 400038, Peoples R China.; Bian, XW; Yu, SC (corresponding author), Army Med Univ, Third Mil Med Univ, Minist Educ, Key Lab Tumor Immunopathol, Chongqing 400038, Peoples R China.

SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (531):

Abstract

MYCN-amplified neuroblastoma (NB) is characterized by poor prognosis, and directly targeting MYCN has proven challenging. Here, we showed that aldehyd......

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