ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance-MedSci.cn

ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

Orme, JJ; Jazieh, KA; Xie, TH; Harrington, S; Liu, X; Ball, M; Madden, B; Charlesworth, MC; Azam, TU; Lucien, F; Wootla, B; Li, YL; Villasboas, JC; Mansfield, AS; Dronca, RS; Dong, HD

Orme, JJ (corresponding author), 200 1st St NW, Rochester, MN 55902 USA.

ONCOIMMUNOLOGY, 2020; 9 (1):

Abstract

ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibi......

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