Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness

Cheng, JJ; Tsuda, M; Okolotowicz, K; Dwyer, M; Bushway, PJ; Colas, AR; Lancman, JJ; Schade, D; Perea-Gil, I; Bruyneel, AAN; Lee, J; Vadgama, N; Quach, J; McKeithan, WL; Biechele, TL; Wu, JC; Moon, RT; Dong, PDS; Karakikes, I; Cashman, JR; Mercola, M

Mercola, M (corresponding author), Sanford Burnham Prebys Med Discovery Inst, 10901 North Torrey Pines Rd, La Jolla, CA 92037 USA.; Mercola, M (corresponding author), Univ Calif San Diego, San Diego, CA 92093 USA.; Mercola, M (corresponding author), Stanford Univ, Cardiovasc Inst, 240 Pasteur Dr, Palo Alto, CA 94305 USA.; Mercola, M (corresponding author), Stanford Univ, Dept Med, 240 Pasteur Dr, Palo Alto, CA 94305 USA.

CELL CHEMICAL BIOLOGY, 2021; 28 (5): 625

Abstract

Wnt signaling plays a central role in tissue maintenance and cancer. Wnt activates downstream genes through beta-catenin, which interacts with TCF/LEF......

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