Modulatory effects of statins on the autophagy: A therapeutic perspective

Ashrafizadeh, M; Ahmadi, Z; Farkhondeh, T; Samarghandian, S

Samarghandian, S (reprint author), Neyshabur Univ Med Sci, Dept Basic Med Sci, Neyshabur 9318614139, Iran.

JOURNAL OF CELLULAR PHYSIOLOGY, 2020; 235 (4): 3157

Abstract

Autophagy is considered as an important mechanism for maintaining homeostasis and responsible for the degradation of superfluous or potentially toxic components and organelles. Autophagy impairment is associated with a number of pathological conditions, such as aging, neurological disorders, cancer, and infection. Autophagy also plays a significant role in cancer chemotherapy. The multiple cancer drugs have been notably developed with the strategy of autophagy modulation. Statins, 3-hydroxy-3-methyl-glutaryl-CoA inhibitors, are known due to their efficacy in decreasing low-density lipoprotein and extensively used for the management of cardiovascular diseases. Statins have other therapeutic and biological activities, such as antioxidant, anti-inflammatory, antitumor, and neuroprotective known as pleiotropic effects. It seems that statins are capable of targeting various signaling pathways in the induction of their great pharmacological effects. At the present study, we demonstrate the therapeutic effects of statins mediated via autophagy regulation.

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