The crystal structure of MICU2 provides insight into Ca2+ binding and MICU1-MICU2 heterodimer formation-MedSci.cn

The crystal structure of MICU2 provides insight into Ca2+ binding and MICU1-MICU2 heterodimer formation

Wu, WP; Shen, QY; Lei, Z; Qi, ZY; Li, D; Pei, HR; Zheng, JM; Jia, ZC

Zheng, JM (reprint author), Beijing Normal Univ, Coll Chem, Beijing, Peoples R China.; Jia, ZC (reprint author), Queens Univ, Dept Biomed & Mol Sci, Kingston, ON, Canada.

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Abstract

The mitochondrial calcium uniporter (MCU) complex mediates the uptake of Ca2+ into mitochondria. Its activity is regulated by a heterodimer of MICU1 a......

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