Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice

Lai, K; Song, XL; Shi, HS; Qi, X; Li, CY; Fang, J; Wang, F; Maximyuk, O; Krishtal, O; Xu, TL; Li, XY; Ni, K; Li, WP; Shi, HB; Wang, LY; Yin, SK

Shi, HB; Yin, SK (corresponding author), Sixth Peoples Hosp Shanghai, Dept Otorhinolaryngol, Shanghai 200032, Peoples R China.; Shi, HB; Yin, SK (corresponding author), Shanghai Jiao Tong Univ, Shanghai 200032, Peoples R China.; Wang, LY (corresponding author), SickKids Res Inst, Program Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada.; Wang, LY (corresponding author), Univ Toronto, Dept Physiol, Toronto, ON M5S 1A1, Canada.

SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (530):

Abstract

Neonatal hyperbilirubinemia is a common clinical condition that can lead to brain encephalopathy, particularly when concurrent with acidosis due to in......

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