Chemical Modulation of Gasdermin-Mediated Pyroptosis and Therapeutic Potential

Ryder, CB; Kondolf, HC; O'Keefe, ME; Zhou, BW; Abbott, DW

Abbott, DW (通讯作者),Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA.

JOURNAL OF MOLECULAR BIOLOGY, 2022; 434 (4):

Abstract

Pyroptosis, a lytic form of programmed cell death, both stimulates effective immune responses and causes tissue damage. Gasdermin (GSDM) proteins are ......

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