Inhibition of proprotein convertase subtilisin/kexin type 9 attenuates neuronal apoptosis following focal cerebral ischemia via apolipoprotein E receptor 2 downregulation in hyperlipidemic mice-MedSci.cn

Inhibition of proprotein convertase subtilisin/kexin type 9 attenuates neuronal apoptosis following focal cerebral ischemia via apolipoprotein E receptor 2 downregulation in hyperlipidemic mice

Wang, L; Wang, Z; Shi, JD; Jiang, Q; Wang, H; Li, X; Hao, D

Wang, L (reprint author), Tianjin Inst Med & Pharmaceut Sci, Cardiovasc & Cerebrovasc Drugs Res & Dev Ctr, 79 Duolun Rd, Tianjin 300020, Peoples R China.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018; 42 (4): 2098

Abstract

The inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) protects a variety of cell types against neuronal apoptosis by binding to apol......

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