Human naive epiblast cells possess unrestricted lineage potential

Guo, G; Stirparo, GG; Strawbridge, SE; Spindlow, D; Yang, J; Clarke, J; Dattani, A; Yanagida, A; Li, MA; Myers, S; Ozel, BN; Nichols, J; Smith, A

Guo, G; Nichols, J; Smith, A (corresponding author), Univ Cambridge, Wellcome MRC Cambridge Stem Cell Inst, Jeffrey Cheah Biomed Ctr, Cambridge CB2 0AW, England.; Nichols, J (corresponding author), Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 1GA, England.; Smith, A (corresponding author), Univ Cambridge, Dept Biochem, Cambridge CB2 1QR, England.; Guo, G; Smith, A (corresponding author), Univ Exeter, Living Syst Inst, Exeter EX4 4QD, Devon, England.

CELL STEM CELL, 2021; 28 (6): 1040

Abstract

Classic embryological experiments have established that the early mouse embryo develops via sequential lineage bifurcations. The first segregated line......

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