Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly

Horn-Ghetko, D; Krist, DT; Prabu, JR; Baek, K; Mulder, MPC; Klugel, M; Scott, DC; Ovaa, H; Kleiger, G; Schulman, BA

Schulman, BA (corresponding author), Max Planck Inst Biochem, Dept Mol Machines & Signaling, Martinsried, Germany.; Schulman, BA (corresponding author), St Jude Childrens Res Hosp, Dept Struct Biol, 332 N Lauderdale St, Memphis, TN 38105 USA.

NATURE, 2021; 590 (7847):

Abstract

E3 ligases are typically classified by hallmark domains such as RING and RBR, which are thought to specify unique catalytic mechanisms of ubiquitin tr......

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