MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming

Zhang, Z; Li, TE; Chen, M; Xu, D; Zhu, Y; Hu, BY; Lin, ZF; Pan, JJ; Wang, X; Wu, C; Zheng, Y; Lu, L; Jia, HL; Gao, S; Dong, QZ; Qin, LX

Dong, QZ; Qin, LX (corresponding author), Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai, Peoples R China.; Gao, S (corresponding author), Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou, Peoples R China.; Dong, QZ; Qin, LX (corresponding author), Fudan Univ, Canc Metastasis Inst, Shanghai, Peoples R China.

BRITISH JOURNAL OF CANCER, 2020; 122 (2): 209

Abstract

Background Mitochondrial dynamics plays an important role in tumour progression. However, how these dynamics integrate tumour metabolism in hepatocell......

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