Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway

Li, PF; Peng, J; Li, YX; Gong, LL; Lv, YL; Liu, H; Zhang, TH; Yang, S; Liu, HC; Li, JL; Liu, LH

Liu, LH (corresponding author), Capital Med Univ, Beijing Chaoyang Hosp, Pharm Dept, Beijing, Peoples R China.; Li, JL (corresponding author), Guollence Pharmaceut Technol Co Ltd, Beijing, Peoples R China.

FRONTIERS IN PHARMACOLOGY, 2021; 12 ():

Abstract

Background: Akebia saponin D (ASD) has a variety of biological activities and great medicinal potential, but its oral bioavailability is so low as to ......

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