Impaired cell fate through gain-of-function mutations in a chromatin reader

Wan, LL; Chong, SS; Xuan, F; Liang, A; Cui, XD; Gates, L; Carroll, TS; Li, YY; Feng, LJ; Chen, GC; Wang, SP; Ortiz, MV; Daley, SK; Wang, XL; Xuan, HW; Kentsis, A; Muir, TW; Roeder, RG; Li, HT; Li, W; Tjian, R; Wen, H; Allis, CD

Wan, LL; Allis, CD (corresponding author), Rockefeller Univ, Lab Chromatin Biol & Epigenet, 1230 York Ave, New York, NY 10021 USA.; Wen, H (corresponding author), Van Andel Inst, Ctr Epigenet, Grand Rapids, MI 49546 USA.; Wan, LL (corresponding author), Univ Penn, Dept Canc Biol, Perelman Sch Med, Philadelphia, PA 19104 USA.

NATURE, 2020; 577 (7788): 121


Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by 'reader' proteins ......

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