An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma

Wen, CL; Huang, K; Jiang, LL; Lu, XX; Dai, YT; Shi, MM; Tang, XM; Wang, QB; Zhang, XD; Wang, PH; Li, HT; Ruan, XX; Wang, LW; Wang, XJ; Wang, Q; Lu, W; Xiang, XQ; Sun, X; Xu, YH; Lai, LH; Zhan, Q; Li, HW; Peng, CH; Chen, J; Huang, JY; Ye, DY; Chen, SJ

Fang, Y; Shen, BY (reprint author), Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Res Inst Pancreat Dis, Shanghai 200025, Peoples R China.; Fang, Y; Shen, BY (reprint author), Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai Inst Digest Surg, Shan

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019; 116 (46): 23264

Abstract

Glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) plays a critical role in cancer metabolism by coordinating glycolysis and biosynthesis. A well-val......

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