Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids

Kuzuya, M; Hirano, H; Hayashida, K; Watanabe, M; Kobayashi, K; Terada, T; Mahmood, MI; Tama, F; Tani, K; Fujiyoshi, Y; Oshima, A

Oshima, A (通讯作者)，Nagoya Univ, Grad Sch Pharmaceut Sci, Dept Basic Med Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan.;Oshima, A (通讯作者)，Nagoya Univ, Cellular & Struct Physiol Inst CeSPI, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648601, Japan.;Oshima, A (通讯作者)，Nagoya Univ, Inst Glyco Core Res iGCORE, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648601, Japan.

SCIENCE SIGNALING, 2022; 15 (720):

Abstract

Pannexin (PANX) family proteins form large-pore channels that mediate purinergic signaling. We analyzed the cryo-EM structures of human PANX1 in lipid......

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