Histamine intolerance or false food allergy with histamine mechanism is defined as symptoms caused by ingestion of food containing histamine at dose well tolerated by healthy subjects. These reactions consist in relatively frequent disease such as chronic urticaria or headache. Prevalence is estimated at 1%. The authors highlight the pathophysiological mechanisms: abnormalities of intestinal absorption of histamine or enzymatic catabolism (diamine oxidase and histamine-N-methyl-transferase), hyper-reactivity to histamine and/or increase of non-specific histamine release. Diagnosis is based on food diary, the exclusion of the main differential diagnosis that is food allergy, and histamine restricted diet. The authors suggest a diet poor in histamine, balanced without excess biogenic amines consumption as recommended by the National health nutrition programme. (C) 2016 Elsevier Masson SAS. All rights reserved.