Binding and structural asymmetry governs ligand sensitivity in a cyclic nucleotide-gated ion channel

Ng, LCT; Zhuang, MY; Van Petegem, F; Li, YX; Accili, EA

Accili, EA (reprint author), Univ British Columbia, Dept Cellular & Physiol Sci, Vancouver, BC, Canada.

JOURNAL OF GENERAL PHYSIOLOGY, 2019; 151 (10): 1190

Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels open more easily when cAMP or cGMP bind to a domain in the intracellular C-terminus......

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