Combinational therapeutic targeting of BRD4 and CDK7 synergistically induces anticancer effects in head and neck squamous cell carcinoma-MedSci.cn

Combinational therapeutic targeting of BRD4 and CDK7 synergistically induces anticancer effects in head and neck squamous cell carcinoma

Zhang, W; Ge, H; Jiang, Y; Huang, R; Wu, YP; Wang, DM; Guo, SS; Li, S; Wang, YL; Jiang, HB; Cheng, J

Cheng, J (corresponding author), Nanjing Med Univ, Affiliated Stomatol Hosp, Dept Oral & Maxillofacial Surg, Nanjing 210029, Jiangsu, Peoples R China.

CANCER LETTERS, 2020; 469 (): 510

Abstract

The bromodomain and extra-terminal domain protein BRD4 has been recognized as a key oncogenic driver and a druggable target against cancer. However, t......

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