Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1 beta is associated with changes in expression of beta-cell maturity genes and associated histone modifications

Urizar, AI; Prause, M; Wortham, M; Sui, YH; Thams, P; Sander, M; Christensen, GL; Billestrup, N

Billestrup, N (reprint author), Univ Copenhagen, Dept Biomed Sci, DK-2200 Copenhagen, Denmark.

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2019; 496 ():

Abstract

Decreased insulin secretory capacity in Type 2 diabetes mellitus is associated with beta-cell dedifferentiation and inflammation. We hypothesize that ......

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