TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis

Jiang, Z; Lim, SO; Yan, MS; Hsu, ENE; Yao, J; Wei, YK; Chang, SS; Yamaguchi, H; Lee, HH; Ke, BZ; Hsu, JM; Chan, LCA; Hortobagyi, GN; Yang, LQ; Lin, CR; Yu, DH; Hung, MECE

Hung, MECE (corresponding author), China Med Univ, 100,Sec 1 Jingmao Rd, Taichung 40406, Taiwan.

JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (8):

Abstract

Immune checkpoint blockade therapy has demonstrated promising clinical outcomes for multiple cancer types. However, the emergence of resistance as wel......

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