miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction

Hong, YM; He, HW; Jiang, GJ; Zhang, H; Tao, WY; Ding, Y; Yuan, DS; Liu, J; Fan, HM; Lin, F; Liang, XT; Li, X; Zhang, YL

Li, X; Zhang, YL (corresponding author), Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Emergency Med, Guangzhou, Guangdong, Peoples R China.; Liang, XT (corresponding author), Tongji Univ, Sch Med, Shanghai East Hosp, Inst Regenerat Med, Shanghai, Peoples R China.

AGING CELL, 2020; 19 (4):

Abstract

Aging impairs the functions of human mesenchymal stem cells (MSCs), thereby severely reducing their beneficial effects on myocardial infarction (MI). ......

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