Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

Li, BS; Brady, SW; Ma, XT; Shen, S; Zhang, YC; Li, YJ; Szlachta, K; Dong, L; Liu, Y; Yang, F; Wang, NL; Flasch, DA; Myers, MA; Mulder, HL; Ding, LX; Liu, YL; Tian, LQ; Hagiwara, K; Xu, K; Zhou, X; Sioson, E; Wang, TY; Yang, L; Zhao, J; Zhang, H; Shao, Y; Sun, HY; Sun, LL; Cai, JY; Sun, HY; Lin, TN; Du, LJ; Li, H; Rusch, M; Edmonson, MN; Easton, J; Zhu, XF; Zhang, JL; Cheng, C; Raphael, BJ; Tang, JY; Downing, JR; Alexandrov, LB; Zhou, BBS; Pui, CH; Yang, JJ; Zhang, JH

Zhang, JH (corresponding author), St Jude Childrens Res Hosp, Dept Computat Biol, MS 1135,Rm IA6038,262 Danny Thomas Pl, Memphis, TN 38105 USA.; Yang, JJ (corresponding author), St Jude Childrens Res Hosp, Dept Pharmaceut Sci, MS 313,Rm I5104,262 Danny Thomas Pl, Memphis, TN 38105 USA.; Pui, CH (corresponding author), St Jude Childrens Res Hosp, Dept Oncol, MS 260,Rm C6056,262 Danny Thomas Pl, Memphis, TN 38105 USA.; Zhou, BBS (corresponding author), Shanghai Childrens Med Ctr, Key Lab Pediat Hematol & Oncol, 8th Fl,Comprehens Med & Res Bldg,1678 Dongfang Rd, Shanghai, Peoples R China.

BLOOD, 2020; 135 (1): 41

Abstract

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 diagnosis-relapse-germline trios......

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