Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs-MedSci.cn

Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs

Scaletti, E; Jemth, AS; Helleday, T; Stenmark, P

Stenmark, P (reprint author), Stockholm Univ, Dept Biochem & Biophys, S-10691 Stockholm, Sweden.; Jemth, AS (reprint author), Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17176 Stockholm, Sweden.

FEBS LETTERS, 2019; 593 (14): 1863

Abstract

Serine hydroxymethyltransferase (SHMT) is the major source of 1-carbon units required for nucleotide synthesis. Humans have cytosolic (SHMT1) and mito......

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