The von Willebrand factor D ' D3 assembly and structural principles for factor VIII binding and concatemer biogenesis

Dong, XC; Leksa, NC; Chhabra, ES; Arndt, JW; Lu, Q; Knockenhauer, KE; Peters, RT; Springer, TA

Peters, RT (reprint author), Bioverativ, 225 2nd Ave, Waltham, MA 02451 USA.; Springer, TA (reprint author), Boston Childrens Hosp, Ctr Life Sci, Room 3103,3 Blackfan Cir, Boston, MA 02115 USA.

BLOOD, 2019; 133 (14): 1523

Abstract

D assemblies make up half of the von Willebrand factor (VWF), yet are of unknown structure. D1 and D2 in the prodomain and D'D3 in mature VWF at Golgi......

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