M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt/GSK-3 beta/beta-catenin pathway in mice

Qian, B; Yang, Y; Tang, NY; Wang, JH; Sun, P; Yang, N; Chen, F; Wu, TJ; Sun, T; Li, YT; Chang, X; Zhu, YX; Zhang, YQ; Han, X

Zhang, YQ; Han, X (corresponding author), Nanjing Med Univ, Dept Biochem & Mol Biol, Key Lab Human Funct Genom Jiangsu Prov, Nanjing, Peoples R China.; Zhang, YQ (corresponding author), Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing, Peoples R China.

DIABETOLOGIA, 2021; 64 (9): 2037

Abstract

Aims/hypothesis Macrophage levels are elevated in pancreatic islets, and the resulting inflammatory response is a major contributor to beta cell failu......

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