The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer

Zhang, JR; Liu, SY; Li, Q; Shi, YL; Wu, YG; Liu, F; Wang, SS; Zaky, MY; Yousuf, W; Sun, QH; Guo, D; Wang, TS; Zhang, YQ; Wang, Y; Li, M; Liu, H

Li, M; Liu, H (corresponding author), Dalian Med Univ, Inst Canc Stem Cell, Affiliated Hosp 2, Dalian, Peoples R China.; Li, M (corresponding author), Dalian Med Univ, Affiliated Hosp 2, Dept Oncol, Dalian, Peoples R China.

CELL DEATH AND DIFFERENTIATION, 2020; 27 (9): 2710

Abstract

ErbB2 overexpression identifies a subclass of breast cancer as ErbB2-positive that is frequently associated with poor prognosis. Current ErbB2-targete......

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