Next generation risk assessment (NGRA): Bridging in vitro points-of-departure to human safety assessment using physiologically-based kinetic (PBK) modelling ? A case study of doxorubicin with dose metrics considerations

Li, HQ; Yuan, HT; Middleton, A; Li, J; Nicol, B; Carmichael, P; Guo, JB; Peng, SQ; Zhang, Q

Peng, SQ (corresponding author), Acad Mil Med Sci, Inst Dis Control & Prevent, Evaluat & Res Ctr Toxicol, Beijing 100071, Peoples R China.; Zhang, Q (corresponding author), Emory Univ, Dept Environm Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.

TOXICOLOGY IN VITRO, 2021; 74 ():

Abstract

Using the chemical doxorubicin (DOX), the objective of the present study was to evaluate the impact of dose metrics selection in the new approach meth......

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