K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice

Xie, J; Shao, Y; Liu, J; Cui, ML; Xiao, XX; Gong, JB; Xue, BH; Zhang, QW; Hu, XW; Duan, HF

Duan, HF (corresponding author), Beijing Inst Radiat Med BIRM, Key Lab Expt Hematol, 27 Taiping Rd, Beijing 100850, Peoples R China.; Hu, XW (corresponding author), Beijing Inst Biotechnol BIB, Lab Cell Engn, 20 Dongdajie St, Beijing 100071, Peoples R China.

SCIENTIFIC REPORTS, 2020; 10 (1):

Abstract

Obesity and its associated metabolic disorders are increasingly impacting public health worldwide. Sphingosine kinase 1 (Sphk1) is a critical enzyme i......

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