Integrin-Linked Kinase Deficiency in Collecting Duct Principal Cell Promotes Necroptosis of Principal Cell and Contributes to Kidney Inflammation and Fibrosis

Huang, M; Zhu, S; Huang, HH; He, JZ; Tsuji, KJ; Jin, WW; Xie, DP; Ham, O; Capen, DE; Lu, WN; Paunescu, TG; Yang, BX; Lu, HAJ

Yang, BX (reprint author), Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, 38 Xueyuan Rd, Beijing 100191, Peoples R China.; Lu, HAJ (reprint author), Massachusetts Gen Hosp, Program Membrane Biol, Dept Med, 185 Cambridge St,CPZN 8150, Boston

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2019; 30 (11): 2073

Abstract

Background Necroptosis is a newly discovered cell death pathway that plays a critical role in AKI. The involvement of integrin-linked kinase (ILK) in ......

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