Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9

Bubeck, F; Hoffmann, MD; Harteveld, Z; Aschenbrenner, S; Bietz, A; Waldhauer, MC; Borner, K; Fakhiri, J; Schmelas, C; Dietz, L; Grimm, D; Correia, BE; Eils, R; Niopek, D

Eils, R; Niopek, D (reprint author), Heidelberg Univ, Inst Pharm & Biotechnol IPMB, Synthet Biol Grp, Heidelberg, Germany.; Eils, R; Niopek, D (reprint author), Heidelberg Univ, Ctr Quantitat Anal Mol & Cellular Biosyst BioQuan, Heidelberg, Germany.; Eils

NATURE METHODS, 2018; 15 (11): 924

Abstract

Anti-CRISPR proteins are powerful tools for CRISPR-Cas9 regulation; the ability to precisely modulate their activity could facilitate spatiotemporally......

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