Preparation of 5 '-deoxy-5 '-amino-5 '-C-methyl adenosine derivatives and their activity against DOT1L

Liu, TC; Xie, WC; Li, C; Ren, HM; Mao, YD; Chen, GH; Cheng, MS; Zhao, DM; Shen, JK; Li, J; Zhou, YB; Xiong, B; Chen, YL

Zhao, DM; Zhou, YB; Xiong, B; Chen, YL (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017; 27 (22): 4960

Abstract

From a readily available 5-C-Me ribofuranoside, we have realized a reliable route to valuable 5'-deoxy-5'-amino-5'-C-methyl adenosine derivatives at g......

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