Increased interleukin-1 beta and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis

Tamai, M; Kobayashi, N; Shimada, K; Oka, N; Takahashi, M; Tanuma, A; Tanemoto, T; Namba, H; Saito, Y; Wada, Y; Okamoto, A; Ida, H; Kondo, K

Kobayashi, N (reprint author), Jikei Univ, Sch Med, Dept Virol, Minato Ku, 3-25-8 Nishi Shimbashi, Tokyo 1058461, Japan.



Human herpesvirus 6B (HHV-6B) causes exanthema subitum in infants and is known to be mildly pathogenic. However, HHV-6B infection can induce febrile seizures in a high percentage of patients, and in rare cases, result in encephalitis. We detected higher levels of interleukin (IL)-1 beta and basic fibroblast growth factor (bFGF) in the cerebrospinal fluid (CFS) of patients with HHV-6B encephalitis when compared to those in patients with non-HHV-6B-induced febrile seizures. In vitro, IL-1 beta and bFGF enhanced HHV-6B gene expression in infected U373 astrocytes during the initial and maintenance phases of infection, respectively. These findings indicated that IL-1 beta and bFGF contribute to HHV-6B growth and the onset of encephalitis. (C) 2017 The Authors. Published by Elsevier Inc.

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