Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy

Hernandez, G; Luo, T; Javed, TA; Wen, L; Kalwat, MA; Vale, K; Ammouri, F; Husain, SZ; Kliewer, SA; Mangelsdorf, DJ

Kliewer, SA; Mangelsdorf, DJ (corresponding author), UT Southwestern Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA.; Kliewer, SA (corresponding author), UT Southwestern Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA.; Mangelsdorf, DJ (corresponding author), UT Southwestern Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA.

SCIENCE TRANSLATIONAL MEDICINE, 2020; 12 (525):

Abstract

The exocrine pancreas expresses the highest concentrations of fibroblast growth factor 21 (FGF21) in the body, where it maintains acinar cell proteost......

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