Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine

Hovhannisyan, Z; Liu, NY; Khalil-Aguero, S; Panea, C; VanValkenburgh, J; Zhang, RY; Lim, WK; Bai, Y; Fury, W; Huang, T; Garnova, E; Fairhurst, J; Kim, J; Aryal, S; Ajithdoss, D; Oyejide, A; Molina-Portela, MD; Hock, E; Poueymirou, W; Oristian, NS; Brydges, S; Liu, X; Olson, W; Yancopoulos, G; Murphy, AJ; Sleeman, MA; Haxhinasto, S

Hovhannisyan, Z; Haxhinasto, S (corresponding author), Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA.

SCIENCE IMMUNOLOGY, 2020; 5 (54):

Abstract

Deficiency in interleukin-36R (IL-36R) antagonist caused by loss-of-function mutations in IL-36RN leads to DITRA (deficiency of IL-36 receptor antagon......

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