Lung Myofibroblasts Promote Macrophage Profibrotic Activity through Lactate-induced Histone Lactylation

Cui, HC; Xie, N; Banerjee, S; Ge, J; Jiang, DY; Dey, T; Matthews, QL; Liu, RM; Liu, G

Liu, G (corresponding author), Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, 901 19th St South,BMR 2 233,Birmingham, Birmingham, AL 35294 USA.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2021; 64 (1): 115

Abstract

Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to their profibrotic phenotype. The primary glycolysis byproduc......

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